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目的:研究葛根素对易中风型自发高血压大鼠(SHRSP)脑缺血中风的影响。方法:结扎动物双侧颈总动脉,造成实验性脑缺血中风。结果:双侧颈总动脉结扎后因缺血性中风而产生痉挛发作和死亡。葛根素可明显延缓动物出现痉挛和死亡的时间,并呈剂量依赖性。结论:葛根素对SHRSP实验性脑缺血引起的中风有保护作用。
Objective: To study the effect of puerarin on cerebral ischemic stroke in spontaneously hypertensive rats (SHRSP). METHODS: Bilateral common carotid arteries were ligated to cause experimental cerebral ischemic stroke. RESULTS: Sputum attack and death occurred due to ischemic stroke after bilateral common carotid artery ligation. Puerarin significantly delays the appearance of delirium and death in animals in a dose-dependent manner. Conclusion: Puerarin has protective effects on stroke induced by cerebral ischemia in SHRSP.