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目的探讨腮腺硬化型黏液表皮样癌(sclerosing mu-coepidermoid carcinoma,SMEC)的临床特点、组织学特征及鉴别诊断。方法采用免疫组化EnVision两步法对SMEC标本进行染色,结合临床资料并复习相关文献,分析其形态学特征及免疫表型。结果肿瘤与周围腮腺组织混杂存在,中央硬化,外周淋巴细胞及少量嗜酸细胞浸润,并见鳞状细胞巢及黏液细胞。免疫表型:黏液细胞CEA、CKL均(+),非角化的表皮样细胞及中间型细胞CEA(-),表皮样细胞CKH(+),Ki-67、c-erbB-2均(-)。结论腮腺SMEC发病率极低,属于低度恶性肿瘤。
Objective To investigate the clinical features, histological features and differential diagnosis of sclerosing mu-coepidermoid carcinoma (SMEC). Methods The immunohistochemical EnVision two-step method was used to stain the SMEC specimens. The clinical data were reviewed and the related literatures were reviewed. Morphological characteristics and immunophenotype were analyzed. Results Tumor mixed with the surrounding parotid gland, central sclerosis, peripheral lymphocytes and a small amount of eosinophilic infiltration, and see the squamous cell nests and mucus cells. Immunophenotype: CEA, CKL (+), non-keratinized epidermoid cells and intermediate cells CEA (-), epidermoid cells CKH (+), Ki-67 and c-erbB- ). Conclusions The incidence of parotid SMEC is very low and is a low-grade malignant tumor.