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肠道缺血是消化道严重的循环障碍。肠道的缺血/再灌注(I/R)是上述情况发生及救治过程中必经的病理生理过程,由此产生的肠屏障功能损伤、肠道细菌和毒素易位及肠源性败血症是导致多器官功能不全综合征的重要原因。因此,寻找保护肠黏膜屏障的方法,减轻肠道I/R对机体的负面作用有重要意义。在传统营养液中加入谷氨酰胺(Gln)可以提高营养支持的效率、降低感染发生率及病死率。现就近年来Gln在外科营养中的研究及对肠道I/R的影响予以综述。
Intestinal ischemia is a serious circulatory disturbance of the digestive tract. Intestinal ischemia / reperfusion (I / R) is a pathophysiological process that occurs in the course of the above and treatment must be passed, resulting in intestinal barrier dysfunction, intestinal bacterial and toxin translocation and enterogenous septicemia is Lead to multiple organ dysfunction syndrome, an important reason. Therefore, looking for ways to protect the intestinal mucosal barrier to reduce the intestinal I / R on the body’s negative effects of great significance. Addition of glutamine (Gln) to traditional nutrient solutions can increase the nutritional support efficiency, reduce the incidence of infection and mortality. In recent years, Gln in surgical nutrition research and the impact on intestinal I / R are reviewed.