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用Ｗｉｓｔａｒ大白鼠６４只，经微量注射６－羟多巴胺入右侧黑质区后，观察大鼠的行为和黑质及尾壳核细胞形态学变化。结果如下：①６４只大鼠中，３５只（５４．７％）恒定转向左侧且结果稳定，与帕金森氏病的症状相类似，被视为帕金森氏病旋转鼠模型。②在旋转鼠右侧黑质和尾壳核内，酪氨酸羟化酶样（多巴胺能）神经元和神经纤维末稍明显减少或消失，而左侧黑质和尾壳核内无明显变化。结果提示：６－羟多巴胺能选择性地损毁多巴胺能神经元及纤维末稍，从而建立稳定的帕金森氏病旋转鼠模型。
Sixty-four Wistar rats were injected with 6-hydroxydopamine into the right substantia nigra region. Morphological changes of the substantia nigra and caudate putamen were observed. The results were as follows: (1) Of the 64 rats, 35 (54.7%) turned to the left and were stable, similar to the symptoms of Parkinson’s disease, and were considered Parkinson’s disease rotarod model. ② In the right substantia nigra and caudate putamen nucleus, tyrosine hydroxylase-like (dopaminergic) neurons and nerve fibers were significantly reduced or disappeared, while there was no significant change in left substantia nigra and caudate putamen . The results suggest that 6-hydroxydopamine can selectively damage dopaminergic neurons and fibroids, so as to establish a stable Parkinson’s disease rat model.