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本研究通过在体回肠肠系膜动脉缺血再灌流（Ｉ／Ｒ）肠管内加压模型，以１２５Ｉ－ＬＰＳ为示踪剂，动态观察肠腔内毒素的转运规律及通里攻下中药承气合剂在这一病理生理过程中的作用。实验结果表明：肠内压在１０ｃｍＨ２Ｏ时，Ｉ／Ｒ模型组的１２５Ｉ－ＬＰＳ入血量、肠外渗漏量、肠组织吸收率均明显高于正常对照组（Ｐ＜０．０１）；承气合剂预处理Ｉ／Ｒ模型组的１２５Ｉ－ＬＰＳ入血量、肠组织吸收率均明显低于Ｉ／Ｒ模型组（Ｐ＜０．０１）。表明肠内压升高对Ｉ／Ｒ肠腔内内毒素移位有促进作用，且随施压时间的延长而增加。承气合剂可减少肠腔内毒素的移位入血。
In this study, 125I-LPS was used as a tracer in the model of intestinal ischemia in ileo-intestinal mesenteric artery ischemia and reperfusion (I/R) to dynamically observe the transport of toxins in the lumen of the intestine. The role in this pathophysiological process. The experimental results showed that when the intestinal pressure was 10cmH2O, 125I-LPS blood volume, intestinal extravasation, and intestinal absorption rate in the I/R model group were significantly higher than those in the normal control group (P<0.01); The 125I-LPS blood intake and intestine tissue absorption rate of the gas mixture pretreatment I/R model group were significantly lower than those of the I/R model group (P<0.01). It was shown that elevated intestinal pressure promoted the translocation of endotoxin in the I/R lumen and increased with the prolonged application of pressure. Chengqi Mixture can reduce the translocation of toxins into the blood in the intestinal lumen.