论文部分内容阅读
目的探讨胃癌组织中癌症高表达蛋白(Hec1)的表达与肿瘤浸润、转移及预后的关系。方法采用免疫组化SP法检测20例正常胃组织、40例癌旁组织及癌组织中Hec1的表达。结果在正常胃、癌旁组织及胃癌组织中,Hec1蛋白的阳性表达率分别为0%,20.0%,67.5%,各组Hec1蛋白的表达差异均有统计学意义(P<0.05)。Hec1蛋白的表达与胃癌的临床病理分期、侵袭转移有关,在发生淋巴道转移及低分化的肿瘤组织中,Hec1蛋白高表达。结论Hec1蛋白的过度表达可能在胃癌的发生和发展中起重要作用,联合应用Hec1蛋白阳性表达率与其临床病理学分级,有助于正确判断患者的预后。
Objective To investigate the relationship between the expression of Hec1 protein and tumor invasion, metastasis and prognosis in gastric cancer. Methods Immunohistochemical SP method was used to detect the expression of Hec1 in 20 normal gastric tissues, 40 adjacent tissues and cancerous tissues. Results The positive rates of Hec1 protein in normal gastric tissues, paracancerous tissues and gastric cancer tissues were 0%, 20.0% and 67.5%, respectively. There were significant differences in the expression of Hec1 protein in each group (P <0.05). The expression of Hec1 protein is correlated with the clinicopathologic stage, invasion and metastasis of gastric cancer. Hec1 protein is highly expressed in the tumor tissues with lymphatic metastasis and poorly differentiated. Conclusion The overexpression of Hec1 protein may play an important role in the carcinogenesis and progression of gastric cancer. The combined application of Hec1 protein and its clinicopathological grade may help to judge the prognosis of patients.