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目的分析血管紧张素转换酶抑制剂(ACEI)联合激素和低分子肝素治疗难治性肾病综合征的临床疗效。方法收集2011年10月至2012年10月洛阳市第六人民医院收治的20例难治性肾病综合征患者的临床资料,比较所有患者1 d内的尿蛋白定量、血浆蛋白、浮肿、肾功能及并发症情况。结果 20例患者经过临床治疗,完全缓解8例(40.00%),基本缓解7例(35.00%),部分缓解3例(12.00%),无效2例(8.00%),总有效率为92.00%。在相关生化指标方面,治疗后明显胜于治疗前,差异有统计学意义(P<0.05)。基本无不良反应。结论 ACEI联合激素和低分子肝素治疗难治性肾病综合征不良反应比较少,疗效显著,值得临床推广。
Objective To analyze the clinical effect of combined angiotensin converting enzyme inhibitor (ACEI) and low molecular weight heparin in the treatment of refractory nephrotic syndrome. Methods The clinical data of 20 patients with refractory nephrotic syndrome admitted to the Sixth People’s Hospital of Luoyang from October 2011 to October 2012 were collected. Urine protein, plasma protein, edema, renal function And complications. Results Twenty patients underwent complete remission in 8 patients (40.00%), 7 patients (35.00%) in complete remission, 3 patients (12.00%) partially relieved and 2 (8.00%) ineffective in 2 patients. The total effective rate was 92.00%. In the relevant biochemical indicators, after treatment was significantly better than before treatment, the difference was statistically significant (P <0.05). The basic no adverse reactions. Conclusion ACEI combined with low molecular weight heparin and heparin therapy for refractory nephrotic syndrome has fewer side effects and significant curative effect, which is worthy of clinical promotion.