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新生儿缺氧缺血性脑病(HIE)及颅内出血是引起新生儿应激性溃疡、消化道出血的主要病因之一,有效预防应激性溃疡的发生是成功抢救新生儿HIE及颅内出血的重要措施之一。本文就甲氰咪胍对新生儿HIE及颅内出血并发应激性溃疡的预防作用进行探讨。 1 临床资料 按照随机抽样原则分甲氰咪胍预防组20例,对照组20例,除9例外,31例病例均经头颅CT证实诊断。两组病例均为根据分度标准选择中度以上的病例。预防组中HIE 8例,并存颅内出血12例;对照组HIE9例,并存颅内出血11例。两组原发病治疗相同。预防组在原发病治疗基础上给予甲氰咪胍10～15mg/kg加入10％葡萄糖液15ml中,每日1次静滴,病情稳定
Neonatal hypoxic-ischemic encephalopathy (HIE) and intracranial hemorrhage are one of the major causes of neonatal stress ulcer and gastrointestinal bleeding. Effective prevention of stress ulcer is the successful rescue of neonatal HIE and intracranial hemorrhage One of the important measures. In this paper, cimetidine neonatal HIE and intracranial hemorrhagic complications of stress ulcer were explored. 1 clinical data in accordance with the principle of random sampling sub-cimetidine 20 cases, 20 cases of control group, with the exception of 9 cases, 31 cases were confirmed by head CT confirmed. Two groups of patients are based on the standard selection of more than moderate cases. Prevention group of HIE 8 cases, coexisting intracranial hemorrhage in 12 cases; control group HIE 9 cases, coexisting intracranial hemorrhage in 11 cases. The same treatment of two primary disease. On the basis of the primary disease treatment, the prophylaxis group was given cimetidine 10-15mg / kg to 15ml of 10% dextrose solution intravenously once a day for stable condition