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目的探讨根除幽门螺杆菌(Hp)后,胃黏膜组织中多胺含量的变化及意义。方法Hp阳性胃溃疡患者58例,测定根除Hp前后胃黏膜多胺含量及组织学检查。结果Hp阳性患者多胺含量明显高于阴性者,根除Hp后显著下降。结论根除Hp感染能够降低胃黏膜的增殖活性,从而降低胃癌的危险性。
Objective To investigate the changes and significance of polyamines in gastric mucosa after eradication of Helicobacter pylori (Hp). Methods Fifty-eight patients with Hp-positive gastric ulcer were enrolled in this study. Gastric mucosal polyamine levels and histological examination before and after eradication of Hp were measured. Results Hp positive patients with polyamine content was significantly higher than negative, significantly reduced after eradication of Hp. Conclusion Eradication of Hp infection can reduce gastric mucosal proliferative activity and thus reduce the risk of gastric cancer.