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目的:探讨表皮生长因子受体Erb B4在人肝内胆管癌(ICC)组织中的表达及意义。方法:采用免疫组化法分别检测24例ICC患者癌组织(ICC组)、癌旁胆管组织(癌旁组)及16例肝内胆管结石患者胆管组织(结石组)中Erb B4的表达,并分析Erb B4表达与ICC患者临床病理因素的关系。结果:Erb B4的强阳性表达率在ICC组中为75.0%,明显高于癌旁组(45.8%)和结石组(37.5%)(均P<0.05);且ICC组胞核Erb B4阳性表达率高于另两组(均P<0.05),而胞膜与胞质Erb B4阳性表达率3组间差异无统计学意义(均P>0.05)。Erb B4的高表达与ICC患者淋巴结转移及TNM分期有关(均P<0.05)。结论:Erb B4的表达增高与核内移与ICC的发生发展以及浸润转移密切相关。
Objective: To investigate the expression and significance of epidermal growth factor receptor Erb B4 in human intrahepatic cholangiocarcinoma (ICC) tissues. Methods: Immunohistochemical method was used to detect the expression of Erb B4 in bile duct tissue (calculus group) in 24 cases of ICC patients, ICC group, paracancer cholangiocarcinoma group and 16 cases of intrahepatic cholelithiasis patients To analyze the relationship between Erb B4 expression and clinical and pathological factors in patients with ICC. Results: The strong positive expression rate of Erb B4 was 75.0% in ICC group, which was significantly higher than that in adjacent group (45.8%) and stone group (37.5%) (all P <0.05). The positive expression of Erb B4 in ICC The rates of positive expression of ErbB4 in cytoplasm and cytoplasm were not significantly different between the two groups (all P <0.05). The overexpression of Erb B4 was associated with lymph node metastasis and TNM stage in patients with ICC (all P <0.05). Conclusion: The increased expression of Erb B4 is closely related to the development of ICM and the infiltration and metastasis of ICC.