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为了探讨抗T淋巴细胞单克隆抗体（简称单抗、SMU3、SMU8）治疗小儿再生障碍性贫血（以下简称再障AA）的关系，本研究对20例再障患儿进行了T细胞亚群测定，并在应用单抗治疗前后与病情转化进行对照。结果表明：患儿T细胞亚群比值失衡，主要表现为T4细胞减少，T8细胞增多，T4／T8比值倒置，患者T8细胞处于激活状态。外周HLA－DR抗原的表达明显高于正常。单抗治疗有效率为68．5％，有效组病儿细胞免疫功能紊乱得到纠正。治疗有效以后病情恶化，T细胞亚群又紊乱。
In order to investigate the relationship between anti-T lymphocyte monoclonal antibody (mAb, SMU3 and SMU8) in the treatment of pediatric aplastic anemia (AA), 20 children with aplastic anemia were enrolled in this study. T cell subsets , And compared with the condition before and after the application of monoclonal antibody treatment. The results showed that: T cell subsets in children with an imbalance ratio, mainly as a decrease in T4 cells, T8 cells increased, T4 / T8 ratio inversion, the patient’s T8 cells are activated. Peripheral HLA-DR antigen expression was significantly higher than normal. Monoclonal antibody treatment efficiency was 68.5%, effective group of children with cellular immune dysfunction corrected. After the treatment of exacerbations, T cell subsets and disorder.