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近年来，国外开展的循环内皮细胞（ＣＥＣ）检测能结合临床研究血管内皮细胞（ＶＥＣ）的变化，具有较高的临床应用价值，但对其基本形态学特性尚待阐明。本文采用细胞培养、免疫组化及扫描电镜等手段，对ＣＥＣ的数量、形态、ⅧＲ：Ａｇ分布及ＣＥＣ的形成过程进行了研究。结果表明：（１）我国健康人群的外周血中存在ＣＥＣ，其值为１．３±０．７／０．９μｌ；（２）ＣＥＣ具有独特的形态特点（与循环血中其它正常血细胞相比），如体大、无核、细胞呈皱缩、拆叠或扭曲状；（３）在脐静脉和ＥＣ培养片中均存在与ＣＥＣ形态极为相似的脱落ＥＣ，提示健康人群外周血中的ＣＥＣ可能来源于正常代谢过程中衰老的ＶＥＣ；（４）从ＶＥＣ向ＣＥＣ过渡是一个渐变的过程，其形态变化主要有细胞肿大、胞膜破坏和胞核脱落等。
In recent years, the detection of circulating endothelial cells (CEC) abroad can be combined with the clinical study of vascular endothelial cells (VEC) changes, has a high clinical value, but its basic morphological characteristics remain to be elucidated. In this paper, the number of CEC, the distribution of ⅧR: Ag and the formation of CEC were studied by means of cell culture, immunohistochemistry and scanning electron microscopy. The results showed that: (1) There is CEC in the peripheral blood of healthy population in China with a value of 1.3 ± 0.7 / 0.9μl; (2) CEC has unique morphological characteristics (compared with other normal blood cells in circulating blood ), Such as large, non-nuclear cells were shrinkage, folding or twisted shape; (3) in the umbilical vein and EC culture sheet are closely related to the shape of CEC shedding EC, suggesting that healthy people in the peripheral blood CEC May be derived from the normal metabolic process of aging VEC; (4) the transition from VEC to CEC is a gradual process, the main morphological changes include cell swelling, cell membrane destruction and nuclear shedding.