给狗一次注射大肠杆菌内毒素5μg/kg,引起肺动脉压和肺血管阻力显著增加,肺动脉嵌压无明显变化。动脉血浆血栓素β_z和6-酮-PGF1α水平及白三烯含量均明显升高。环氧合酶抑制剂消炎痛可缓解肺动脉压力升高;脂氧合酶抑制剂乙胺嗪,阻断白三烯生成及部分抑制血栓素B_2的增加,可以阻止肺动脉高压形成。提示:内毒素所致肺动脉高压与血栓素A_2和白三烯有关。 A single injection of E. coli endotoxin 5μg / kg, causing pulmonary hypertension and pulmonary vascular resistance increased significantly, no significant changes in pulmonary arterial pressure. Arterial plasma thromboxane β_z and 6-keto-PGF1α levels and leukotriene levels were significantly increased. Indomethacin, an cyclooxygenase inhibitor, can relieve pulmonary hypertension; lipoxygenase inhibitor diethylcarbamazine, which blocks the production of leukotrienes and partially inhibits the increase of thromboxane B 2, can prevent the formation of pulmonary hypertension. Tip: endotoxin-induced pulmonary hypertension with thromboxane A 2 and leukotrienes.