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[目的]观察六味地黄丸与生活方式干预治疗糖耐量异常疗效。[方法]使用随机平行对照方法,将80例门诊患者按病志号按抽签方法随机分为两组。对照组40例干预生活方式,戒烟戒酒,严格按糖尿病饮食。治疗组40例六味地黄丸(北京同仁堂,120g/瓶),6g/次,2次/d;干预生活方式同对照组。连续治疗干预1年为1疗程。观测临床症状、空腹血糖、糖负荷后2h血浆血糖、总胆固醇、甘油三酯、临床转归、不良反应,治疗干预1疗程,判定疗效。[结果]治疗组显效34例,有效5例,无效1例,总有效率97.50%;对照组显效2例,有效3例,无效35例,总有效率12.50%;治疗组疗效优于对照组(P<0.05)。FBG、2h PBG均明显下降(P<0.05),治疗组下降优于对照组(P<0.05);TC、TG均明显下降(P<0.05),组间无明显差异(P>0.05)。对照组糖耐量转为正常2例(5%),仍为IGT 29例(72.5%),转为DM 9例(22.5%),DM年转率22.5%;六味地黄丸组糖耐量转为正常27例(67.5%),仍为IGT11例(27.5%),转为DM2例(5%),DM平均年转率为5%;DM平均年转率治疗组低于对照组(P<0.05),发生DM危险对照组是六味地黄丸组的4.5倍(OR=4.5)。[结论]六味地黄丸与干预生活方式治疗糖耐量异常,疗效满意,无副作用,值得推广。
[Objective] To observe the therapeutic effect of Liuweidihuang Pill and lifestyle intervention on impaired glucose tolerance. [Method] Using randomized parallel control method, 80 outpatients were randomly divided into two groups according to their disease index by lottery method. Control group 40 cases intervention lifestyle, quit smoking and drinking, strictly according to the diabetic diet. Treatment group, 40 cases of Liu Wei Di Huang Wan (Beijing Tong Ren Tang, 120g / bottle), 6g / time, 2 times / d; lifestyle intervention with the control group. Continuous treatment intervention for 1 year for a course of treatment. Observe the clinical symptoms, fasting blood glucose, blood glucose, total cholesterol, triglyceride, clinical outcome, adverse reactions and therapeutic intervention for 1 course of treatment after 2h of glucose load. [Results] In the treatment group, 34 cases were markedly effective, 5 cases were effective, 1 case was ineffective, and the total effective rate was 97.50%. In the control group, 2 cases were markedly effective, 3 cases effective, 35 ineffective and the total effective rate was 12.50% (P <0.05). FBG and 2h PBG were significantly decreased (P <0.05), the treatment group was better than the control group (P <0.05); TC, TG were significantly decreased (P <0.05). The glucose tolerance of the control group turned normal (2%), still 29 (72.5%) were IGT, 9 (22.5%) DM and 22.5% 27 cases (67.5%) remained IGT in 11 cases (27.5%), DM2 cases (5%), DM average annual conversion rate was 5%; DM average annual conversion rate was lower in the treatment group than in the control group (P <0.05) , The occurrence of DM risk control group was 4.5 times the Liu Wei Di Huang Wan group (OR = 4.5). [Conclusion] Liuweidihuang Pill and intervention lifestyle treatment of impaired glucose tolerance, satisfactory efficacy, no side effects, it is worth promoting.