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目的探讨急性心肌梗死患者直接经皮冠状动脉成形术(PTCA)联合脂微球载体前列腺素 E_1(Lipo-PGE_1)治疗后心电图 ST 段改变的临床意义。方法前瞻性研究76例行直接 PTCA 联合 Lipo-PGE1治疗的急性心肌梗死患者术后30 min 心电图 ST 段的改变情况,分析其与治疗效果、心肌损害程度、心功能及预后的关系。结果急性心肌梗死患者直接 PTCA 联合 Lipo-PGE1治疗后心电图 ST 段明显下降者治疗效果好,心肌损害程度减轻,心功能较好。结论直接 PTCA 联合脂微球载体前列腺素 E1治疗急性心肌梗死患者,术后心电图 ST 段改变可作为判定疗效、心肌灌注情况,进而判定预后的指标之一。
Objective To investigate the clinical significance of ST segment changes in patients with acute myocardial infarction after direct percutaneous transluminal coronary angioplasty (PTCA) and liposome-loaded prostaglandin E_1 (Lipo-PGE_1) treatment. Methods 76 cases of acute myocardial infarction patients treated with direct PTCA combined with Lipo-PGE1 were prospectively studied. The changes of ST segment in electrocardiogram at 30 minutes after operation were analyzed. The relationship between ST segment and therapeutic effect, myocardial damage, cardiac function and prognosis were prospectively analyzed. Results The patients with acute myocardial infarction treated with direct PTCA combined with Lipo-PGE1 significantly reduced the ST segment electrocardiogram. The treatment effect was good, the extent of myocardial damage was relieved, and the heart function was better. Conclusion Direct PTCA combined with lipid microspheres carrier prostaglandin E1 in patients with acute myocardial infarction, postoperative ECG ST segment changes can be used as a judgment of efficacy, myocardial perfusion, and then determine the prognosis of the index.