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目的探讨硫酸氨基葡萄糖辅助治疗类风湿关节炎的临床疗效,及其对患者骨质破坏进展、炎症因子的影响。方法将2010年1月~2013年5月在大庆油田总医院内湿科住院治疗的102例类风湿关节炎病例随机分为治疗组和对照组,对照组单纯应用免疫抑制剂治疗(甲氨蝶呤联合来氟米特),治疗组在免疫抑制剂治疗基础上加用硫酸氨基葡萄糖,比较两组患者治疗前后的关节疼痛改善情况、炎性细胞因子水平。结果两组患者疼痛评分及炎性介质白细胞介素(IL-6)、肿瘤坏死因子(TNF-α)水平在治疗后较治疗前降低,治疗组TNF-α水平降低更明显,差异均有统计学意义(P<0.05)。结论硫酸氨基葡萄糖联合免疫抑制剂治疗类风湿关节炎可缓解骨质破坏,降低炎性因子水平。
Objective To investigate the clinical efficacy of glucosamine sulfate in the treatment of rheumatoid arthritis and its effect on the progress of bone destruction and inflammatory factors in patients. Methods From January 2010 to May 2013, 102 cases of rheumatoid arthritis hospitalized in Daqing Oilfield General Hospital were randomly divided into treatment group and control group. The control group was treated with immunosuppressive drugs alone Combined with leflunomide). The treatment group added glucosamine sulfate on the basis of immunosuppressive therapy. The improvement of joint pain and inflammatory cytokines before and after treatment were compared between the two groups. Results The scores of pain and the levels of interleukin (IL) -6 and tumor necrosis factor (TNF-α) in the two groups were lower after treatment than those before treatment, and the levels of TNF-α in the treatment group decreased more obviously Significance (P <0.05). Conclusion Glucosamine sulfate combined with immunosuppressive agents in the treatment of rheumatoid arthritis can reduce bone destruction, reduce the level of inflammatory cytokines.