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目的:观察血必净注射液对呼吸机相关性肺炎(VAP)的影响,探索较单用抗菌药物更有效的治疗方法。方法:选择2006-2013年我院老年病科VAP 51例。治疗组26例在应用抗菌药物基础上给予血必净注射液静脉滴注。对照组25例单用抗菌药物治疗。结果:治疗组的VAP总有效率65.38%,对照组为44.00%,两组比较有显著性差异(P<0.01)。治疗组抗菌药物平均使用时间8天,对照组抗菌药物平均使用时间10天,两组比较差异显著(P<0.05)。治疗期间未发现治疗组有明显副作用,包括皮肤过敏、出血等。结论:抗菌药物联合血必净注射液治疗VAP疗效肯定,有效缩短了抗菌药物的使用时间,减少了抗菌药物用量,值得临床推广。
Objective: To observe the effect of Xuebijing injection on ventilator-associated pneumonia (VAP) and to explore more effective treatment than antimicrobial agents alone. Methods: 51 cases of VAP in our hospital from 2006 to 2013 were selected. In the treatment group, 26 cases were given Xuebijing Injection intravenously on the basis of antibiotics. Control group of 25 cases of antimicrobial drugs alone. Results: The total effective rate of VAP was 65.38% in the treatment group and 44.00% in the control group, there was significant difference between the two groups (P <0.01). The mean duration of use of antibacterials in the treatment group was 8 days, while that in the control group was 10 days. The difference between the two groups was significant (P <0.05). The treatment group did not find significant side effects during treatment, including skin allergies, bleeding and so on. Conclusion: The combination of antibacterials and Xuebijing injection for the treatment of VAP affirmed, effectively shorten the use of antimicrobial agents, reduce the amount of antimicrobial agents, worthy of clinical promotion.