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目的：观察葛根素注射液对急性脑梗死（ACI）的治疗作用。方法：44例ACI患者随机分为两组，葛根素治疗组（A组）22例应用葛根素500mg加5％葡萄糖溶液静脉满注，每日1次，共14天；低分子右旋糖酐组（B组）22例应用低分子右旋糖酐500mL，方法与疗程同A组。分别于治疗前及治疗2疗程后作神经功能缺损评分；同时观察血流动力学、心电图、梗死灶体积大小等指标的变化以评定临床疗效。结果：治疗后A组有效率82％，明显高于B组45％，（P＜0．01）。且A组治疗后血浆黏度、全血高切黏度、全血低切黏度及纤维蛋白原定量均显著下降；且CT扫描病灶比治疗前缩小校B组明显。结论：葛根素能明显改善ACI患者的血流动力学指标，且安全、疗效可靠，可作为ACI治疗的一种新选择。
Objective: To observe the therapeutic effect of puerarin on acute cerebral infarction (ACI). Methods: Forty-four patients with ACI were randomly divided into two groups: 22 patients in puerarin group (group A) received intravenous infusion of puerarin 500mg plus 5% glucose solution once daily for 14 days; and low molecular dextran group (B Group) 22 cases of low molecular weight dextran 500mL, method and treatment with the same group. Respectively, before and after treatment for 2 courses of neurological deficit score; the same time, hemodynamic, electrocardiogram, infarct size and other indicators of changes in the assessment of clinical efficacy. Results: After treatment, the effective rate of group A was 82%, which was significantly higher than that of group B (45%, P <0.01). After treatment, the plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity and fibrinogen quantification decreased significantly; and CT scan lesion was more obvious than that before treatment. Conclusion: Puerarin can significantly improve the hemodynamic parameters of patients with ACI, and safe, reliable, and can be used as a new treatment for ACI.