采用差速离心分离技术与中子活化分析法(NAA)相结合的方法分析了人肝25种元素,并用标准参考物保证结果的准确性.分析结果表明,大多数元素在各亚细胞组分中并非均匀分布.As、Au、Co、I、Mg、Mo、Sb、Sc在细胞核和线粒体浓度最高.Al、As、Au、Ba、Fe、I、La、Mg、Mn、Sb、Se在胞液中浓度最低,生物体内主要以离子形式存在的Br、Cl、K、Na则在胞液中浓度最高.值得注意的是,As在细胞核中大量聚集,是其它组分的2～4倍;而La与Fe则在微粒体中富集. The methods of differential centrifugation and neutron activation analysis (NAA) were used to analyze the 25 elements of human liver, and the accuracy of the results was guaranteed by using standard reference materials.The analysis results showed that most of the elements in the subcellular fractions The distributions of As, Au, Co, I, Mg, Mo, Sb and Sc in the nucleus and mitochondria were the highest The concentration of Br, Cl, K, Na in the body is the highest in the cytosol.It is noteworthy that As accumulates in the nucleus a lot, which is 2 to 4 times of other components; La and Fe are enriched in microsomes.