关于绝经妇女雌激素替代治疗的利益与危险,不同意见存在已久。观察性研究始终反映,接受该治疗的与未接受者比较,绝经妇女降低死亡率,减少心血管病的发生。但多项随机化临床试验的结果又使人失望,因为预防动脉粥样硬化的一级、二级预防大多反映危险(血栓栓塞、恶性肿瘤、脑卒中) With regard to the benefits and dangers of estrogen replacement therapy in postmenopausal women, different opinions have existed for a long time. Observational studies have consistently shown that menopausal women reduce mortality and reduce the incidence of cardiovascular disease compared with non-recipients who receive the treatment. However, the results of several randomized clinical trials are disappointing as the primary and secondary prevention of atherosclerosis mostly reflects the risk (thromboembolism, malignancy, stroke)