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地高辛和奎尼丁同时应用的患者大多数发生血浆地高辛水平增高100～150％,但不同患者的增加率有所不同。 地高辛和奎尼丁同用时,地高辛肾清除率减少25～40％,但其减少似乎不是由于肾小球过滤率的减少。奎尼丁可使地高辛总清除率平均减少33～64％。奎尼丁和地高辛同用使后者的有效性提高15％,而且有些研究表明,奎尼丁能促进地高辛的吸收。动物实验表明,奎尼丁能抑制地高辛经浆膜粘膜的主动转移。根据上述机理,随胆汁分泌的地高辛将受到抑制,地高辛的肠肝循环将中断,从而使其吸收量增加,或使其肠排除量减少。
In most patients with digoxin and quinidine, plasma digoxin levels increase by 100-150%, but the rate of increase varies from patient to patient. When digoxin is used in combination with quinidine, digoxin renal clearance is reduced by 25 to 40%, but the reduction does not appear to be due to a decrease in glomerular filtration rate. Quinidine can reduce the total digoxin total clearance rate of 33 to 64%. Quinidine and digoxin use the latter to increase the effectiveness of 15%, and some studies have shown that quinidine can promote the absorption of digoxin. Animal experiments show that quinidine can inhibit the active transfer of digoxin by serosal mucosa. According to the above mechanism, digoxin secreted with bile is inhibited and digoxin enterohepatic circulation is interrupted, thereby increasing its absorption or decreasing its intestinal elimination.