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SR_(8390)50,100,200mg·kg~(-1)iv可剂量依赖性地降低清醒自发性高血压大鼠的血压,高剂量组的作用持续时间超过60min。SR_(8390)25至398mg·kg~(-1)和16至251mg·kg~(-1)iv亦可分别降低麻醉自发性高血压大鼠和犬的血压,其作用呈明星的量效关系,且对犬的降压作用较对大鼠的作用强,降舒张压的作用较降收缩压的作用强。结果表明,SR_(8390)有较强而持久的降血压作用,其作用符合多数药物对大动物的作用较对小动物的作用强的规律,也符合药物作用的量效规律。
SR 8339, 100, 100 and 200 mg · kg -1 could reduce the blood pressure of conscious spontaneously hypertensive rats in a dose-dependent manner, and the effect of high dose group was longer than 60 minutes. SR-8390, 25 to 398 mg · kg -1 and 16 to 251 mg · kg -1 could also reduce the blood pressure of anesthetized spontaneously hypertensive rats and canine, respectively, with a dose-effect relationship , And the antihypertensive effect on dogs stronger than the role of rats, lowering the role of diastolic blood pressure than the role of systolic blood pressure. The results showed that SR_ (8390) had a strong and sustained antihypertensive effect, which was in line with the rule that the effect of most drugs on the large animals was stronger than that on the small animals and also the rule of the dose-effect of the drug.