Chemotherapy and target therapy for hepatocellular carcinoma:New advances and challenges

来源 :World Journal of Hepatology | 被引量 : 0次 | 上传用户:cds123
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Primary liver cancer is one of the commonest causes of death.Hepatocellular carcinoma(HCC) accounts for 90% of primary liver cancers.For patients with unresectable or metastatic HCC,conventional chemotherapy is of limited or no benefit.Sorafenib is the only systemic treatment to demonstrate a statistically significant but modest overall survival benefit,leading to an era of targeted agents.Many clinical trials of targeted drugs have been carried out with many more in progress.Some drugs like PTK787 showed potential benefits in the treatment of HCC.Despite these promising breakthroughs,patients with HCC still have a dismal prognosis.Recently,both a phase Ⅲ trial of everolimus and a phase Ⅱ clinical trial of trebananib failed to demonstrate effective antitumor activity in advanced HCC.Sorafenib still plays a pivotal role in advanced HCC,leading to further explorations to exert its maximum efficacy.Combinations targeted with chemotherapy or transarterial chemoembolization is now being tested and might bring about advances.New targeted agents such as mammalian target of rapamycin inhibitors are under investigation,as well as further exploration of the mechanism of hepatocarcinogenesis. Primary liver cancer is one of the commonest causes of death. Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers. For patients with unresectable or metastatic HCC, conventional chemotherapy is of limited or no benefit. demonstrates aces significant but modest overall survival benefit, leading to an era of targeted agents. Many clinical trials of targeted drugs have been carried out with many more in progress. Home drugs like PTK787 showed potential benefits in the treatment of HCC. breakthroughs, patients with HCC still have a dismal prognosis. Both immediately a, both a phase Ⅲ trial of everolimus and a phase Ⅱ clinical trial of trebananib failed to demonstrate effective antitumor activity in advanced HCC, Sorafenib still plays a pivotal role in advanced HCC, leading to further explorations to exert its maximum efficacy. Combinations targeted with chemotherapy or transarterial chemoembolization is now being tested and might bring about advances.New targeted agents such as mammalian target of rapamycin inhibitors are under investigation, as well as further exploration of the mechanism of hepatocarcinogenesis.
其他文献
动画电影《疯狂动物城》艺术性的再现了“乌托邦”式的人类生存世界,影片影像符号的隐喻意义、偏见主题的表达以及解构主义手法的运用让影片具有典型的欧美文学批评的人文内
[摘要]怎样才能让学生既能“动”得了,又能“动”得好,并能达到“动”的最佳效果呢?一、讨论小组的建立要合理;二、调动学生的“思维参与”;三、讨论的时机要恰当;四、讨论的方法要科学;五、讨论的氛围要和谐;六、要培养学生“三会”。  [关键词]数学课堂 思维参与 讨论    《标准》基本理念第一条中用比以前更为明确的语言提出:“使数学教育面向全体学生,实现——人人学有价值的数学;人人都能获得必需的数学
摘要:英国艺术学家克莱夫·贝尔于一百年前撰写了《艺术》一书,该书奠定了他形式主义美学的历史地位,其内容充分体现出贝尔对艺术史深厚的理解、对哲学理论独到的继承以及艺术作品的敏锐判断力。本文将以《艺术》一书出发,在概述书中内容的基础上剖析书中的美学思想,并着重于贝尔对“艺术与社会”之间的关系进行思考与讨论,以及对当下艺术研究发展的意义。  关键词:克莱夫·贝尔 有意味的形式 艺术与社会  中图分类号:
目的:双酚A(Bisphenol A,BPA)是一种常见的环境内分泌干扰物(Environmental endocrine disruptors,EEDs),对女性生殖内分泌系统有潜在的影响。本文通过大鼠卵巢内膜间质细胞及颗粒细
本文研究目的:对比分析男性和女性类风湿关节炎的临床特点,探讨二者存在的差异性,指导临床决策。 研究方法: 采用回顾性分析方法,对95例男性和248例女性RA患者的临床表现和
期刊
[摘要]新课程改革要求不同的学生在教学上得到不同的发展,注重培养和发展学生的创新意识和实践能力,充分发挥学生的想象能力,让学生掌握课堂的自主权,在课堂中能自由地飞翔,大胆地去发现问题、提出问题、解决问题。  [关键词]学生 语文课堂 主导者    新课程改革要求不同的学生在教学上得到不同的发展,注重培养和发展学生的创新意识和实践能力,充分发挥学生的想象能力,让学生掌握课堂的自主权,在课堂中能自由地
背景:休克是外科危重病最常见的病理生理过程,休克导致的死亡率占危重病死亡率的第一位。细胞因子是一种信号转导分子,过度的细胞因子表达则通过免疫应答机制引起组织细胞损伤,是
2019年11月9日至24日,“第五届学院的精神·视界——十大美术学院研究生优秀作品展”在青岛市举行.作为国内高等美术院校研究生层次教学成果的重要展示之一,该展览得到了社会
“云南省第十一届民族民间歌舞乐展演”所呈现的成果是令人欣喜的.通过“巡礼”展演的舞蹈部分,可以窥见云南少数民族浓烈生命情调于艺术中的种种体现.在展演宏观背景下对若