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背景:吉兰-巴雷综合征(Guillain-Barresyndrome,GBS)是急性弛缓性瘫痪的特有变化,造成患者运动、感觉功能障碍,严重者可致死亡,据统计年发病率为0.4/10万～2.0/10万人口。研究GBS的地区性流行病学特征对于康复预防具有实际意义。目的:描述中国哈尔滨市GBS的流行病学特征。设计:调查研究。单位:哈尔滨医科大学第一临床医学院神经内科和瑞典Huddinge大学医学院神经内科。对象:在哈尔滨市及周围5个行政县的5410910人口中建立疾病监测体系。描述GBS患者的流行病学特征。符合Asbury的GBS诊断标准者共有72例。在报告医院寻找与患者年龄相差5岁以内同性别的患者作对照。干预:接收到病例报告后,医生对初筛患者进行临床检查,最后确诊。并采集外周血样及/或脑脊液标本,同时填写GBS临床流行病学调查表。记录患者的一般情况(姓名、年龄及性别等)、前驱症状、发病时的临床表现、病程特点、治疗情况及电生理检查等。主要观察指标:①发病率。②年龄发布。③前驱病史。④临床表现。⑤实验室检查。⑥临床病程。结果:哈尔滨市GBS年发病率为0.67/10万人口。患者的年龄为2～71岁,中位年龄30岁,平均(31.74±18.78)岁。0～9岁组GBS的年发病率最高,为0.89/10万人口。GBS的季节分布以秋季及夏季为主。53例(74.6%)患者在发病前1～
BACKGROUND: Guillain-Barre syndrome (GBS) is a peculiar change in acute flaccid paralysis and causes movement and sensory dysfunction in patients. In severe cases, it may cause death. According to the statistics, the incidence rate is 0.4 / 2.0 / 10 million population. Studying the regional epidemiological features of GBS is of practical significance for rehabilitation prevention. Objective: To describe the epidemiological characteristics of GBS in Harbin, China. Design: Research. SETTING: Department of Neurology, First Clinical College of Harbin Medical University and Department of Neurology, School of Medicine, Huddinge University, Sweden. PARTICIPANTS: A disease surveillance system was set up in 5410910 people in 5 administrative districts of and around Harbin. Describe the epidemiological characteristics of patients with GBS. In line with Asbury GBS diagnostic criteria a total of 72 cases. In the reporting hospital to find patients with the same age difference within 5 years of age as a control. Intervention: After receiving the case report, the doctor performed a clinical examination on the patients who were initially screened and finally confirmed the diagnosis. And collect peripheral blood samples and / or cerebrospinal fluid samples, and fill out the GBS clinical epidemiological questionnaire. Record the patient’s general condition (name, age and gender, etc.), prodromal symptoms, clinical manifestations at onset, course characteristics, treatment and electrophysiological examination. MAIN OUTCOME MEASURES: ① morbidity. ② age release. ③ precursor history. ④ clinical manifestations. ⑤ laboratory tests. ⑥ clinical course. Results: The annual incidence of GBS in Harbin was 0.67 per 100 000 population. The patient’s age ranged from 2 to 71 years, with a median age of 30 years (mean, 31.74 ± 18.78) years. The highest annual incidence of GBS in 0-9 age group was 0.89 per 100 000 population. The seasonal distribution of GBS is mainly in autumn and summer. 53 cases (74.6%) of patients before the onset of 1 ~