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采用犬失血性休克输血复苏模型，观察了硫氮酮（Ｄｉｌｔｉａｚｅｍ，ＤＺ）对休克犬肝、肾、心、肺４个器官组织超微结构及组织中丙二醛（ＭＤＡ）含量和黄嘌呤氧化酶（ＸＯ）活性的影响。结果显示：ＤＺ可使休克犬各器官组织超微结构的损伤性改变明显减轻；ＤＺ处理组各器官组织中ＭＤＡ含量和ＸＯ活性均显著低于对照组。表明ＤＺ对失血性休克犬多个器官具有保护作用，该效应与其抑制ＸＯ活性和氧自由基介导的脂质过氧化反应有关。
The hemorrhagic shock model of blood transfusion in dogs was used to observe the effects of Diltiazem (DZ) on the ultrastructure of liver, kidney, heart and lungs and the content of malondialdehyde (MDA) and xanthine oxidation Effect of enzyme (XO) activity. The results showed that DZ could significantly reduce the ultrastructural damage in various organ tissues of shock dogs. The content of MDA and the activity of XO in various tissues of DZ-treated group were significantly lower than those of the control group. This indicates that DZ has a protective effect on multiple organs in hemorrhagic shock, which is related to the inhibition of XO activity and oxygen free radical-mediated lipid peroxidation.