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目的观察慢性马兜铃酸肾病患者中恶性肿瘤发生情况及其特点。方法集中我科收治的81例慢性马兜铃酸肾病患者,分析研究其中恶性肿瘤发生人数、肿瘤的发生部位、病理类型、年龄性别情况、与服药时间数量是否有关等条件。结果慢性马兜铃酸肾病患者中恶性肿瘤发生率高,且以50岁以上女性发生率高;以泌尿系统肿瘤居多;恶性肿瘤的病理类型以移行上皮癌为主,同时发现有少数磷癌、腺癌(系直肠癌及肺癌患者):恶性肿瘤的发生与服用含马兜铃酸的药物的种类、剂型、服药时间长短、服药的量、肾功能损伤轻重关系不密切。结论慢性马兜铃酸肾病患者中恶性肿瘤发生率较高,尤其以泌尿系统恶性肿瘤发生率为主,肿瘤的病理类型以移行上皮癌为主,但同时也发现少数其他部位、其他病理类型的恶性肿瘤。
Objective To observe the occurrence and characteristics of malignant tumors in patients with chronic aristolochic acid nephropathy. Methods 81 patients with chronic aristolochic acid nephropathy admitted to our department were enrolled in this study. The incidence of malignant tumor, the location of the tumor, pathological type, age and sex, and the time of taking the drug were analyzed. Results The incidence of malignant neoplasms in patients with chronic aristolochic acid nephropathy was high, and the incidence was high in women over 50 years of age. The majority of urological tumors were found. The pathological types of malignant neoplasms were mainly transitional cell carcinomas, Adenocarcinoma (Department of rectal cancer and lung cancer): The incidence of malignant tumors and taking aristolochic acid drugs, dosage forms, the length of time taken, the amount of medication, the severity of renal dysfunction is not closely related. Conclusions The incidence of malignant tumors in patients with chronic aristolochic acid nephropathy is high, especially in the incidence of urological malignancies. The pathological type of the tumor is mainly transitional cell carcinoma, but a few other parts of the neoplasm are found. Other pathological types Malignant tumor.