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由于甲癣的感染位置深在,局部外用药不能有效地渗透入甲板,故有必要口服抗菌药物来治疗。terbinafine是一种新的丙烯胺抗真菌剂,近来经临床使用表明它对甲癣是有效的。它抑制角鲨烯环氧化酶(一种在真菌麦角甾醇生物合成中的关键酶)而发挥其抗真菌作用。为了确定药物最佳剂量及治疗时间,terbinafine与指甲结合的动力学测定是很重要的。然而用一般化学方法(1M NaOH),甚或加用超声波或温热处理,都难以使甲标本良好溶解,以保证最佳的药物萃取。本文对5名自愿者的40余份从甲远端修剪下的标本10～20mg,加入标准
Because of the deep infection of onychomycosis, topical drug can not effectively penetrate the deck, it is necessary oral antibiotics to treat. Terbinafine is a new allyl amine antifungal agent that has recently been shown to be effective against onychomycosis on clinical use. It inhibits squalene cyclooxygenase, a key enzyme in fungal ergosterol biosynthesis, and exerts its antifungal effect. Kinetic determination of terbinafine binding to nails is important in order to determine the optimal dose and duration of treatment. However, with normal chemical method (1M NaOH), or even with ultrasonic or warm treatment, it is difficult to dissolve a specimen well, in order to ensure the best drug extraction. This article on the five volunteers more than 40 copies of specimens from the remote end of 10 ~ 20mg, adding the standard