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In order to develop novel spirocyclic tetronic acid lead compounds,a series of new spirocyclic tetronic acid derivatives containing oxime ether moiety was synthesized and bioassayed.The structures of 16 target compounds were characterized by 1H NMR spectra,13C NMR spectra and high-resolution mass spectrometer(HRMS).Preliminary bioassays indicated that most of the title compounds displayed excellent insecticidal activity against Aphis fabae and Nilaparvata lugens at 100 mg/L.In particular,compound 6k showed the similar activity(LC50=6.87 mg/L) against A.fabae as the spirotetramat(LC50=4.56 mg/L) and had better effects(LC50=l.64 mg/L) against N.lugens in comparison with spirotetramat(LC50=7.90 mg/L).The study showed that compound 6k exhibited more promising and broad-spectrum insecticide activity and may serve as a new insecticidal agent for sucking pests.