疱疹性角膜炎是近年来致盲的主要病因之一。目前,随着抗疱疹病毒制剂的发展,已有几种对抗此病毒的方法,然而,在活动性疱疹感染被根除后,常遗留未愈的角膜上皮缺损。有些病例,上皮修复是迟缓的,有的甚至根本不修复。近代治疗这种持续性上皮缺损主要是些消极疗法,如戴软性接触镜、眼罩或用粘性滴剂、滑润剂,目的在于保护角膜免受外界刺激,以待上皮再生。兔角膜实验提示纤维结合素有利于角膜上皮移行。为了评价它对疱疹性角膜炎后未愈上皮缺损的临床疗效,本文对此作了临床研究。纤维结合素(Fibronectin)眼药水是用明胶偶联琼脂糖凝胶亲和色层法和凝胶过滤法,从病人 Herpes keratitis is one of the major causes of blindness in recent years. Currently, with the development of anti-herpes virus preparations, there are several ways to combat this virus. However, unhealed corneal epithelial defects often remain after the active herpetic infection has been eradicated. In some cases, epithelial repair is slow, and some are not even repaired at all. Modern treatment of this persistent epithelial defects are mainly passive therapy, such as wearing soft contact lenses, goggles or sticky drops, lubricants, the purpose is to protect the cornea from external stimuli, to be epithelial regeneration. Corneal experiments in rabbits suggest that fibronectin is beneficial to corneal epithelial migration. In order to evaluate its clinical efficacy of unprocum epithelial defects after herpes keratitis, this article made a clinical study. Fibronectin eye drops are gelatin-coupled agarose affinity chromatography and gel filtration from the patient