【摘 要】
：
Sixteen novel 6- and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their cytotoxicities were evaluated in vitro agains
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Sixteen novel 6- and 2-(1-acylsulfanylalkyl)-5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized.Their cytotoxicities were evaluated in vitro against BEL-7402,HT-29 and SPC-A1 cell lines.The pharmacological results showed that most of the prepared compounds displayed the excellent selectivity for HT-29 cell line.Compound lab exhibited the most potent antitumor activity among the tested compounds.
Sixteen novel 6- and 2- (1-acylsulfanylalkyl) -5,8-dimethoxy-1,4-naphthoquinones were designed and synthesized. Their cytotoxicities were evaluated in vitro against BEL-7402, HT-29 and SPC-A1 cell lines. The pharmacological results showed that most of the prepared compounds showed the excellent selectivity for HT-29 cell line. Compound lab exhibited the most potent antitumor activity among the tested compounds.
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