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目的研究长期配戴(>5 a)软性角膜接触镜(SCL)大学生与未配戴SCL大学生眼表泪膜的差异,探讨SCL长期配戴对眼表泪膜的影响及可能机制。方法依据SCL戴镜时间将SCL戴镜者区分为<5 a组、5～10 a组和>10 a组,共3组。对正常对照组(35人70眼)和病例组(66人132眼)的泪膜破裂时间(BUT)、角膜荧光素染色(FLS)试验和基础泪液分泌试验(Schirmer I test)结果进行比较。结果软性角膜接触镜戴镜时间<5 a组Schirmer I test、FLS与正常对照组比较差异无统计学意义(P值均>0.05),其余各戴镜组BUT、Schirmer I test、FLS与正常对照组差异均有统计学意义(P值均<0.01)。结论长期配戴软性角膜接触镜会引起泪膜功能下降和角膜上皮损伤,且戴镜时间越长,损害越大。
Objective To investigate the differences of ocular surface tear films among long-term wearing (> 5 years) soft contact lens (SCL) and non-wearing SCL students, and to explore the possible effects of long-term SCL on ocular surface tear film. Methods According to the SCL wearing time, SCL wearing glasses were divided into 5 groups, 5 ~ 10 a group and> 10 a group, a total of 3 groups. The tear film break-up time (BUT), corneal fluorescein staining (FLS) test and basal tear secretion test (Schirmer I test) were compared between the normal control group (35 eyes) and the case group (66 eyes). Results Compared with the normal control group, the Schirmer I test and FLS in soft contact lens wearing time <5 a were not significantly different (all P> 0.05), and the other BUT, Schirmer I test, FLS and normal The differences between the control group were statistically significant (P <0.01). Conclusion Long-term wearing soft contact lens will cause the drop of tear film function and corneal epithelial damage, and the longer wear lens, the greater the damage.