论文部分内容阅读
目的研究聚乙二醇化艾塞那肽(PB199)长期给药对肥胖恒河猴的减肥作用。方法一个月内每周一次sc PB199,观察其对肥胖恒河猴体重、腹部脂肪体积、摄食量、血糖和血脂等肥胖相关指标的影响。结果给药一个月后,模型对照组动物的体重与给药前比增加1.34%,3、6μg·kg-1PB199组猴的体重与给药前比分别降低5.14%、5.68%,较模型对照组的差异显著(P<0.05)。与给药前比,3、6μg·kg-1PB199、艾塞那肽、奥利司他组猴的腹部皮下脂肪体积下降率分别为42.1%、42.2%、39.0%、41.8%,腹腔内脂肪的体积下降率分别为20.8%、20.8%、16.9%、20.5%,各组较模型对照组的差异显著(P<0.05)。结论一个月连续给药PB199对肥胖恒河猴具有显著的减肥作用。
Objective To study the effect of long-term pegylated exenatide (PB199) on obesity in rhesus monkeys. Methods Sc PB199 was administered once a week for one month to observe the effects of body weight, abdominal fat volume, food intake, blood sugar, and lipids on obesity-related indicators of rhesus monkeys. Results One month after administration, the body weight of the model control group increased by 1.34% compared with the pre-administration, while the body weight and pre-administration ratio of the 3,6 μg · kg-1 PB199 group decreased by 5.14% and 5.68%, respectively. Compared with the model control group The difference was significant (P <0.05). The abdomen subcutaneous fat volume decreased by 42.1%, 42.2%, 39.0% and 41.8%, respectively, compared with those before administration in 3,6 μg · kg-1 PB199, exenatide and orlistat groups The rate of volume decrease was 20.8%, 20.8%, 16.9% and 20.5% respectively. The difference between the two groups was significant (P <0.05). Conclusion Continuous administration of PB199 for one month has a significant weight-loss effect on obese rhesus monkeys.