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本文观察了长期低剂量γ射线照射和照射加电击对老年前期(18～21月龄)大鼠血浆性激素水平、肝微粒体混合功能氧化酶(MFO)活力以及组织脂质过氧化物的影响。长期照射加电击使雄性大鼠血浆睾酮水平明显降低(p<0.05),照射与照射加电击均使雄鼠肝微粒体MFO活力明显下降(p<0.05)。长期低剂量γ射线照射和照射加电击组的睾丸自由基浓度较对照组明显升高(p<0.05),长期照射使雄性大鼠肝匀浆与微粒体,睾丸匀浆与线粒体的脂质过氧化物较对照组明显增高,但照射加电击组的脂质过氧化物较照射组(以及对照组)明显下降。实验结果说明照射与照射加电击对老年前期大鼠的作用有所不同,这些环境因素具有加速老化的作用。
In this paper, the effects of long-term low-dose γ-rays irradiation and electric shock on the levels of plasma sex hormones, mixed-function oxidase (MFO) activity and lipid peroxidation in presenile period rats (18-21 months old) were observed. Long-term exposure to electrostimulation reduced the level of plasma testosterone in male rats (p <0.05), and decreased the MFO activity of male mice (p <0.05) by irradiation and irradiation. Long-term low-dose γ-ray irradiation and irradiation plus shock group testicular free radical concentration was significantly higher than the control group (p <0.05), long-term exposure to male rat liver homogenates and microsomal, testicular homogenates and mitochondrial lipid Oxide significantly increased compared with the control group, but the irradiation with the shock group of lipid peroxides than the irradiation group (and the control group) decreased significantly. The experimental results show that irradiation and irradiation plus electric shock have different effects on presenile rats, and these environmental factors have the effect of accelerating aging.