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对肺恶性肿瘤及正常肺组织中蛋白激酶Ｃ的活性进行了对照研究。发现肺恶性肿瘤组织胞浆中的ＰＫＣ活性明显升高，Ｐ＜０．０５；胞膜中仅肉瘤组织ＰＫＣ活性显著升高，而肺鳞癌、腺癌组织胞膜中ＰＫＣ活性与正常肺组织无明显差异。另外，利用Ｗｅｓｔｅｒｎｂｌｏｔ法对ＰＫＣ亚型的分析表明：肺恶性肿瘤及正常肺组织中至少含有ＰＫＣ－α及ＰＫＣｐ－β而不含ＰＫＣ－ε，且ＰＫＣ－α及ＰＫｃ－β在肺恶性肿瘤中的含量较正常有不同程度的增加，其中ＰＫＣ－α出现膜转移。说明ＰＫＣ在肺恶性肿瘤发生机制中可能起重要的调控作用。
A comparative study of the activity of protein kinase C in lung cancer and normal lung tissue was performed. The activity of PKC in the cytoplasm of malignant lung tumors was significantly increased (P<0.05). The PKC activity in the sarcoma tissue was significantly increased in the membrane, whereas the PKC activity in the squamous cell carcinoma and adenocarcinoma tissues was normal. No significant difference. In addition, analysis of PKC isoforms by Western blot indicated that lung cancers and normal lung tissues contain at least PKC-α and PKCp-β but no PKC-ε, and that PKC-α and PKc-β are present in lung malignancies. The content of the protein increased to a different degree than normal, and PKC-α showed membrane metastasis. This suggests that PKC may play an important regulatory role in the pathogenesis of lung malignancy.