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目的 使大鼠慢性萎缩性胃炎 (CAG)证病结合模型更好地模拟临床病、证和症病结合的实际。造模方法的设计思路 :①慢性造模 :“慢性”并非仅为疾病的一个简单性质 ,由于它为时间维度 ,而使疾病病理立体化。所以 ,本实验证、病和症病结合模型均选择较长的造模时间。结果显示各实验组动物胃粘膜均未见出血及溃疡、糜烂 ,各脏器组织不以渗出、坏死为主要病理。②CAG造模 :癌前病变乃至癌变只是虚证的结果和终点 ,致癌物质只是致虚物质的特例。因此 ,我们尽量采用一般的致CAG因素而非致癌物质来诱发肠化病理。在CAG证病结合模型的评价上还注意与CAG相关的机体整体性变化。③证候造模 :脾虚证、肝郁证、肾虚证造模方法均为较成熟方法 ,又均据本实验要求和预试验结果 ,延长了造模时间。④证病结合造模 :临床未将肾虚证作为CAG的主要证候 ,我们依据对肾虚证本质的反重演律理解 ,认为CAG ,特别是有癌前病变的CAG其病理本质应是肾虚证。并注意了病与证的造模因素应尽量达到有机结合 ,包括 :CAG造模因素与虚证造模的一致性 ;虚证造模因素与CAG造模的一致性
OBJECTIVE: To make the model of chronic atrophic gastritis (CAG) syndrome in rats better simulate the reality of combination of clinical disease, syndrome and disease. Modeling method of design ideas: ① chronic modeling: “chronic” is not just a simple nature of the disease, because it is the time dimension, and disease pathology three-dimensional. Therefore, this demonstration, the combination of disease and disease models are to choose a longer modeling time. The results showed that all the animals in the experimental group showed no bleeding and ulcer, erosion, no exudation and necrosis in all organs. ② CAG modeling: precancerous lesions and even cancer is just the result and end point of deficiency syndrome, carcinogens are only a special case of induced substances. Therefore, we try to use the general cause of CAG rather than carcinogens to induce intestinal pathology. In the CAG syndrome evaluation model also pay attention to the CAG-related changes in the overall body. ③ syndrome modeling: spleen deficiency syndrome, liver depression syndrome, kidney deficiency syndrome modeling methods are more mature methods, but also according to the requirements of the experiment and the pre-test results, extending the modeling time. ④ syndrome combined with modeling: Clinical does not kidney deficiency syndrome as the main syndrome of CAG, we based on the essence of the inverse syndrome of kidney dyslexia understanding, that CAG, especially with precancerous lesions of the CAG pathological essence should be kidney deficiency syndrome. And pay attention to disease and syndrome modeling factors should be as far as possible to achieve organic combination, including: CAG modeling factor and deficiency syndrome modeling consistency; deficiency syndrome factors and CAG modeling consistency