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目的探讨亚临床型甲状腺功能减退症对妊娠过程及结局的影响。方法将212例亚临床型甲状腺功能减退孕妇随机平均分为治疗组与对照组,并选取同期正常妊娠孕妇100例作为正常组,治疗组给予左甲状腺素钠片口服治疗,对照组不给予左甲状腺素治疗,对比3组孕妇妊娠期并发症及妊娠结局。结果对照组妊娠期高血压、子痫前期、妊娠期糖尿病、胎儿生长受限、妊娠期贫血发生率、早产、流产、剖宫产率均显著高于治疗组与正常组(P<0.05),而顺产率显著低于治疗组与正常组(P<0.05);对照组新生儿出生体重、Apgar评分均显著低于治疗组与正常组(P<0.05)。结论亚临床型甲状腺功能减退明显增加不良妊娠结局发生,对SCH孕妇应早期诊断、早期治疗,以降低不良妊娠结局发生率,建议妇女在妊娠前、妊娠早期常规进行TSH检查以保证孕产妇与后代的健康。
Objective To investigate the effect of subclinical hypothyroidism on the course of pregnancy and its outcome. Methods A total of 212 pregnant women with hypothyroidism were randomly divided into treatment group and control group. 100 pregnant women of the same period were selected as the normal group. The treatment group was treated with levothyroxine sodium tablets orally, while the control group was not given the left thyroid Su treatment, compared with three groups of pregnant women complications and pregnancy pregnancy outcome. Results The gestational hypertension, preeclampsia, gestational diabetes mellitus, fetal growth restriction, the incidence of anemia during pregnancy, preterm birth, miscarriage and cesarean section rate in the control group were significantly higher than those in the treatment group and the normal group (P <0.05) While the birth rate was significantly lower than the treatment group and the normal group (P <0.05). The birth weight and Apgar score in the control group were significantly lower than those in the treatment group and the normal group (P <0.05). Conclusion Subclinical hypothyroidism significantly increased the incidence of adverse pregnancy, early diagnosis of SCH pregnant women should be early treatment to reduce the incidence of adverse pregnancy outcomes, women are recommended before pregnancy, pregnancy routine TSH check to ensure that pregnant women and offspring Health.