研究证实肝细胞癌（HCC）杂合性缺失和胰腺癌（PC）频繁的等位基因缺失涉及染色体13q．缺失图谱分析分离出HCC中该染色体臂上常见的两个缺失区。域．一是含有RB1座位的14q，另一区域与14q相邻．Zhang等报道HCC中罕见RB基因体细胞突变．提示这种肿瘤涉及另外一肿瘤抑制基因。最 Studies have confirmed that loss of heterozygosity in hepatocellular carcinoma (HCC) and frequent allele deletions in pancreatic cancer (PC) involve chromosome 13q. Deletion mapping analysis isolated two common missing regions on the chromosome arm in HCC. area. One is 14q with RB1 and the other is adjacent to 14q. Zhang et al. reported a rare somatic mutation in the RB gene in HCC. This suggests that this tumor involves another tumor suppressor gene. most