Convenient synthesis of some optically active 1,4-benzodiazepin-2,5-diones

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Isatoic 酐与几 l 氨基的酸被反应给相应(2S )-N-(o-aminobenzoyl)-2-alkyl-aminoacetic 酸。后者混合物在倒流温度下面与 phosphoryl 被对待负担得起 cyclized 产品,(3S )-3-alkyl-3,4-dihydro-1H-1,4-benzodiazepin-2,5-diones。
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