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本文报告用吡喹酮粗粉片(颗粒直经为50～100微米)临床治疗日本血吸虫病176例(一例晚血,其它均为慢性早期,其中22例有加杂症),按总剂量60毫克/公斤,分为4次口服之二日疗法,其临床副反应轻微,所有的副反应之发生率及发生之规律性与范围,以及对肝功能与心电图之无显著影响等,均与已有资料之吡喹酮细粉片等剂量同疗法者相似。治毕3月后复查62例的粪孵阴转率为100%,6月后粪阴率(查59例)为96.56%,其疗效与细粉片亦一致。而粗粉片之原药因减少气流粉碎一道工序,又能避免损耗3—5%的吡喹酮原药,因此我们认为,此药的粗粉片较细粉片为好。
In this paper, 176 cases of schistosomiasis japonica (one case of late blood and the others of chronic early stage, and 22 cases of additional disease) were treated with praziquantel coarse powder (50-100 micrometers straight), and the total dose was 60 Mg / kg, divided into four oral administration of the second day, the minor clinical side effects, the incidence of all the side effects and the occurrence of the rules and scope, and no significant effect on liver function and ECG, are with Information on the praziquantel powder and other doses similar to the therapy. Six months after the completion of the treatment review, 62 cases of feces and hatching negative conversion rate was 100%, June fecal negative rate (check 59 cases) was 96.56%, its efficacy and fine powder is also consistent. The coarse powder of the original drug to reduce air flow smashing a process, but also to avoid 3-5% of the original praziquantel, so we believe that this medicine coarse powder is better than fine powder.