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目的:探讨中性粒细胞计数与淋巴细胞计数比值（neutrophil to lymphocyte ratio，NLR）、血小板计数与淋巴细胞计数比值（platelet to lymphocye ratio，PLR）鉴别低于8月龄婴儿畸胎瘤良恶性的临床应用。方法:回顾性分析52例畸胎瘤患儿临床资料和30例体检为健康儿童的NLR、PLR数据。52例畸胎瘤患儿中男16例，女36例；年龄范围在8 d至8个月。根据术后病理结果，将0~Ⅱ级畸胎瘤患儿纳入良性畸胎瘤组（44例），Ⅲ级畸胎瘤及卵黄囊瘤患儿纳入恶性畸胎瘤组（8例）。30例健康儿童纳入健康对照组，其中男12例，女18例；年龄范围在21 d至7个月。对数据进行卡方检验，组间比较采用n t检验。采用ROC曲线评估NLR、PLR对鉴别畸胎瘤良恶性的效能，采用Kaplan-Meier绘制生存曲线，组间的比较采用Log-rank检验。n 结果:卡方检验结果显示，畸胎瘤良恶性与NLR（n χ2=5.89，n P=0.015）、PLR （n χ2=7.91，n P＝0.005）有关系，血清甲胎蛋白与NLR（n χ2=5.39，n P=0.020）、PLR（n χ2=5.13，n P=0.024）有关系。恶性畸胎瘤组的NLR为1.66±1.63，良性畸胎瘤组的NLR为0.90±0.71，健康对照组的NLR为0.25±0.14，三组间两两比较，差异有统计学意义（n P均<0.05）；恶性畸胎瘤组的PLR为139.67±66.00，良性畸胎瘤组的PLR为85.34±41.47，健康对照组的PLR为66.54±19.83，三组间两两比较，差异有统计学意义（n P均<0.05）。Pearson相关性分析结果显示，NLR与PLR呈正相关（r=0.767，n P<0.05）。甲胎蛋白、NLR和PLR诊断畸胎瘤良恶性灵敏度（87.5%）相同，甲胎蛋白、NLR、PLR诊断畸胎瘤良恶性特异度分别为81.8%、59.1%、65.9%，即甲胎蛋白诊断畸胎瘤良恶性特异度较NLR、PLR高。n 结论:对于低于8月龄婴儿，NLR、PLR升高提示畸胎瘤恶性可能，可以将测定NLR、PLR作为一种新型诊断方法帮助术前鉴别畸胎瘤良恶性。“,”Objective:To explore the clinical applications of neutrophil- to- lymphocyte rate (NLR) and platelet- to- lymphocye rate (PLR) in differentiating benign and malignant teratomas of infants aged under 8 months.Methods:Clinical data of 52 children with teratoma and NLR and PLR data of 30 healthy controls were reviewed retrospectively. Among 52 children with teratoma, there were 16 males and 36 females with an age range of 8 days to 8 months. According to postoperative pathological results, children with grade 0~Ⅱ teratoma were assigned into benign teratoma group (n= 44) while those with grade Ⅲ teratoma and yolk sac tumor malignant teratoma group (n=8). Among 30 healthy controls, there were 12 males and 18 females with an age range of 21 days to 7 months. Chi-square test was employed for data processing and t- test utilized for inter- group comparison. Receiver operating characteristic (ROC) curve was utilized for evaluating the efficacy of NLR/PLR in differentiating benign and malignant teratomas. Kaplan-Meier was used for plotting a survival curve and log-rank test for inter-group comparison.Results:Chi-square test indicated that benign and malignant teratomas were correlated with NLR (n χ2=5.89, n P=0.015) and PLR (n χ2=7.91, n P=0.005) and serum alpha-fetoprotein (AFP) was correlated with NLR (n χ2=5.39, n P=0.020) and PLR (n χ2=5.13, n P= 0.024) . NLR of malignant teratoma group was (1.66±1.63) , NLR of benign teratoma group (0.90± 0.71) and NLR of healthy control group (0.25±0.14) . The difference was statistically significant (n P< 0.05) . PLR of malignant teratoma group was (139.67±66.00) , PLR of benign teratoma group (85.34±41.47) and PLR of healthy control group (66.54±19.83) . The difference was statistically significant (n P<0.05) . Pearson\' s correlation analysis indicated that NLR was positively correlated with PLR (r=0.767,n P<0.05) . AFP, NLR and PLR offered the same sensitivity (87.5%) in the diagnosis of benign and malignant teratomas. And the specificity of AFP, NLR and PLR for diagnosing benign and malignant teratomas were 81.8%, 59.1% and 65.9% respectively. It implied that AFP had a higher specificity than NLR/PLR in the diagnosis of benign and malignant teratomas.n Conclusions:For infants aged under 8 months, elevations of NLR/PLR hint at a possibility of malignancy teratoma. And the preoperative determination of NLR/PLR may be used as a new diagnostic method to help distinguish benign and malignant teratomas.