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胃癌是常见的恶性肿瘤,其发病率具有明显的区域性.河北省赞皇县是胃癌高发区,胃癌年平均死亡率为59/10万,部分行政乡内可高达126.95/10万.我们以往研究显示,该地区胃癌高发与杂色曲霉及其毒素有关.p53是抑癌基因,该基因突变、丢失可导致细胞恶变,由于野生型p53蛋白产物半衰期短,只有6～20min,因此用免疫荧光和组化方法检测不到,而突变型的p53蛋白半衰期延长可达6h,所以检测到p53蛋白水平升高,则说明该基因发生了突变.目前发现很多致癌物
Gastric cancer is a common malignancy, and its incidence is obviously regional. Zanhuang County of Hebei Province is a high incidence area of gastric cancer. The average annual mortality rate of gastric cancer is 59/100,000, and some administrative townships can reach 126.95/100,000. Studies have shown that the high incidence of gastric cancer in this area is related to Aspergillus flavus and its toxins. p53 is a tumor suppressor gene. Mutation and loss of this gene can lead to cell malignant transformation. Because the wild type p53 protein product has a short half-life of only 6 to 20 minutes, immunofluorescence is used. However, the half-life of the mutant p53 protein was prolonged up to 6 h, so detection of elevated p53 protein indicates that the gene has been mutated. Many carcinogens have been discovered so far.