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目的：制备卡托普利缓释片，测定其体外溶出释放。方法：通过测定卡托普利释放度，筛选缓释材料的处方组成。结果：处方４（硬脂酸－聚丙烯酸树脂Ⅱ２∶１）和处方６（硬脂酸－乙基纤维素５∶１）制得的片剂ｔ５０和ｔｄ分别为３．０４ｈ和４．７９ｈ及３．６２ｈ和５．５２ｈ，普通片ｔ５０和ｔｄ为０．１８ｈ和０．２０ｈ。结论：硬脂酸中添加聚丙烯酸树脂Ⅱ（２∶１）或乙基纤维素（５∶１）制得的骨架片明显延缓了卡托普利的体外释放，其释放过程符合一级动力学。
Objective: To prepare captopril sustained-release tablets and determine its dissolution and release in vitro. Methods: By measuring the release of captopril, the formulation of the sustained-release material was screened. Results: Tablets t50 and td of Formulation 4 (stearic acid-polyacrylic resin II 2: 1) and Formulation 6 (stearic acid-ethyl cellulose 5: 1) were 3.04 h and 4.79 h and 3.62h and 5.52h, common tablets t50 and td of 0.18h and 0.20h. Conclusion: The matrix tablets prepared by adding polyacrylic resin Ⅱ (2:1) or ethyl cellulose (5:1) to stearic acid can delay the in vitro release of captopril, and its release process accords with the first order kinetics .