在慢性感染性疾病中,患者往往存在免疫功能异常,表现为药物治疗反应差,于是治疗性疫苗又重新引起了人们的兴趣。治疗性疫苗通过使用新型佐剂、载体、树突细胞过继免疫、同种异体免疫治疗等方法,改善抗原呈递细胞(APC)功能,改变患者免疫耐受情况,从而刺激机体恢复特异性免疫应答,达到根除病原、防止复发的目的。 In chronic infectious diseases, patients often have immune dysfunction, manifested as poor response to drug treatment, so the therapeutic vaccine has re-attracted people’s interest. Therapeutic vaccines can improve antigen-presenting cell (APC) function and change immune tolerance of patients by using new adjuvants, carriers, adoptive immunity of dendritic cells and allogeneic immunotherapy to stimulate the body to restore specific immune response, To eradicate the pathogen to prevent the recurrence of the purpose.