黑棘皮病是一种少见的皮肤疾病,极少累及口腔组织,其特征为皮肤及黏膜的乳头状瘤样增生。黑棘皮病分为良性和恶性两种类型,无特效治疗方法。本文报道2例口腔黏膜黑棘皮病,分别为57岁男性,有口腔黏膜表现并伴有肺癌和纵隔淋巴结转移;57岁女性,有口腔黏膜表现并伴有糖尿病。采用中西医结合治疗后,两个病例临床体征均有改善。 Acanthosis nigricans is a rare skin disease that rarely affects oral tissues and is characterized by papilloma-like hyperplasia of the skin and mucous membranes. Acanthosis nigricans is divided into two types of benign and malignant, no effective treatment. Two cases of acanthosis nigricans were reported in this paper. They were 57-year-old male with oral mucosa accompanied by lung cancer and mediastinal lymph node metastasis. The 57-year-old female had oral mucosa with diabetes. After using the combination of traditional Chinese and Western medicine, the clinical signs of both cases were improved.