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目的:探讨血浆胃动素(MTL)和血清胃泌素(GAS)在儿童支气管哮喘中的水平变化,以阐明胃肠激素与支气管哮喘患儿胃肠功能的关系。方法:应用放射免疫分析(R IA)检测98例哮喘患儿MTL和GAS的水平,其中76例患儿通过平卧或抬高床脚进行吞钡X线检查,并对喘息发作的次数、年龄、严重复发性哮喘,结合伴有反胃烧心等食管炎症状的患儿做好详细的统计学处理。结果:哮喘患儿无男女性别差异。哮喘有症状和钡餐阳性者与对照组比较P<0.001,哮喘无症状组与对照组及哮喘有症状组与无症状组比较也有显著性差异。哮喘有症状组血浆MTL和血清GAS水平明显低于对照组和哮喘无症状组,组间比较均有显著性差异(P<0.001)。结论:经观察发现哮喘反复发作可引起血浆MTL和血清GAS水平的严重降低,支气管哮喘伴发胃食管反流(GER)与哮喘反复发作引起血MTL和GAS水平降低有密切的相关性,胃肠激素水平降低是哮喘引发GER的关键所在,而GER又可触发和加剧喘息的发作。
Objective: To investigate the changes of plasma motilin (MTL) and serum gastrin (GAS) in children with bronchial asthma to clarify the relationship between gastrointestinal hormones and gastrointestinal function in children with bronchial asthma. Methods: Radioimmunoassay (RIA) was used to detect the levels of MTL and GAS in 98 asthmatic children. Among them, 76 children underwent barium X-ray examination by supine or elevated bed feet. The number of wheezing episodes, age, Severe recurrent asthma, combined with nausea heartburn and other symptoms of esophagitis in children with detailed statistical treatment. Results: There was no gender difference in children with asthma. Asthma symptoms and barium meal positive compared with the control group P <0.001, asthma asymptomatic group and the control group and asthma symptomatic group and asymptomatic group also had significant differences. The levels of plasma MTL and serum GAS in asthmatic group were significantly lower than those in control group and asymptomatic asthma group (P <0.001). Conclusions: It has been observed that repeated episodes of asthma can cause severe reduction of plasma MTL and serum GAS level. There is a close correlation between the bronchial asthma associated with gastroesophageal reflux (GER) and the reduction of serum MTL and GAS caused by repeated episodes of asthma. Gastrointestinal Hormone levels reduce the key to trigger GER asthma, and GER can trigger and exacerbate the episode of wheezing.