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天然来源的四氢呋喃型木脂素是由两分子的苯丙素单元氧化聚合而成的次生代谢产物,主要存在于樟科、木兰科、胡椒科、葫芦科、肉豆蔻科、瑞香科、菊科、木犀科、忍冬科、马兜铃科等植物中。其具有较强的生物活性,包括抗肿瘤、抗氧化、抗炎、神经保护、杀虫、雌激素样作用等,已逐渐引起药学工作者的广泛关注。经系统文献调研,从提取分离、结构特点、植物来源等方面对四氢呋喃型木脂素类化合物进行综述,为其深入研究及合理开发利用提供参考依据。
The natural source of tetrahydrofuran-type lignan is two molecules of phenylpropanoid oxidative polymerization of secondary metabolites, mainly in Lauraceae, Magnoliaceae, Pepper families, Cucurbitaceae, Nutmeg Branch, Daphne, Dichunceae Section, Oleaceae, Lonicerae, Aristolochiaceae and other plants. Its strong biological activity, including anti-tumor, anti-oxidation, anti-inflammatory, neuroprotection, insecticidal and estrogen-like effects, has gradually attracted wide attention from the pharmaceutical workers. Based on systematic literature review, the research on tetrahydrofuran-type lignans from the aspects of extraction and separation, structural characteristics, plant origin and so on, provide a reference for further research and rational development and utilization.