1982年以来,第3代头孢烯类抗生素开始用于临床.它对β-内酰胺酶稳定,且为β-内酰胺酶的强力诱导剂.因此,随着其使用,耐药菌的出现便成为问题.特别是绿脓杆菌、沙雷氏菌、肠杆菌中出现许多对β-内酰胺类、氨基糖苷类抗生素耐药菌株.本文研究了1985年度临床分离的各种细菌对第1、2、3代头孢烯类抗生素的敏感性,并与1983年研究结果比较,以检查目前是否存在对第3代头孢烯类抗生素的耐药性. Since 1983, the third generation of cephem antibiotics began to be used clinically, which is stable to β-lactamase and is a potent inducer of β-lactamase. Therefore, with its use, emergence of resistant bacteria Become a problem, especially Pseudomonas aeruginosa, Serratia bacteria, Enterobacteriaceae appeared on the β-lactams, aminoglycoside antibiotic-resistant strains.In this paper, the clinical isolation of bacteria in 1985 on the first 1,2 , Third generation cephem antibiotics, and compared with the results of the 1983 study to check whether there is currently the third generation of cephem antibiotic resistance.