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目的:分析新生儿呼吸窘迫综合征(NRDS)院内感染的临床特点、危险因素,为制定防治措施提供依据。方法:对2011年3月至2013年9月我院NICU收治的第一诊断为NRDS的238例患儿的临床资料进行回顾性分析,根据发生院内感染(44例)和未发生院内感染(194例)进行院内感染部位、危险因素及病原菌的分析。结果:NRDS患儿的院内感染率为18.49%,住院相关院内感染率为8.5例次/千日,机械通气相关院内感染率为14.4例次/千日,中心静脉置管相关院内感染率为0.3例次/千日;感染部位以血液为主(48.89%),其次为呼吸道(33.33%);病原菌以革兰阴性菌为主(76.19%),其中肺炎克雷伯菌占40.48%。结论:NRDS院内感染发生率明显高于其他疾病院内感染发生率。胎龄小、出生体质量低、肠外营养等是发生院内感染的危险因素。
Objective: To analyze the clinical features and risk factors of neonatal respiratory distress syndrome (NRDS) nosocomial infection and provide evidence for the establishment of prevention and treatment measures. Methods: The clinical data of 238 children with NRDS first diagnosed in NICU from March 2011 to September 2013 in our hospital were retrospectively analyzed. According to the data of nosocomial infection (n = 44) and nosocomial infection (n = 194) Cases) nosocomial infection site, risk factors and pathogenic bacteria analysis. Results: The nosocomial infection rate was 18.49% in infants with NRDS, 8.5 hospital nosocomial infections per 1,000 days, the hospital-acquired nosocomial infection rate was 14.4 cases / day, and the nosocomial infection rate in central venous catheter was 0.3 (48.89%), followed by the respiratory tract (33.33%). Gram-negative bacteria were the main pathogens (76.19%), of which Klebsiella pneumoniae accounted for 40.48%. CONCLUSIONS: The incidence of nosocomial infections in NRDS is significantly higher than those in other nosocomial infections. Small gestational age, low birth weight, parenteral nutrition and other risk factors for nosocomial infections.