论文部分内容阅读
对38例肝硬化患者进行了外周血淋巴细胞内腺苷脱氨酶（ADA）活性和T淋巴细胞亚群测定．并对LADA活性与T淋巴细胞亚群间的关系进行了研究．结果表明：肝硬化患者LADA活性均显著高于正常组（P＜0．01），外周血淋巴细胞CD3、CD4、CD8及CD4／CD8比值也存在显著差异（P＜0.01）．相关分析显示：LADA活性与CD4／CD8比值也呈现高度的负相关（P＜0．01）．提示肝硬化患者LADA活性升高与T淋巴细胞亚群比例失调关系密切．
Peripheral blood lymphocyte adenosine deaminase (ADA) activity and T lymphocyte subsets were measured in 38 patients with cirrhosis. The relationship between LADA activity and T lymphocyte subsets was also studied. The results showed that the activity of LADA in patients with cirrhosis was significantly higher than that in the normal group (P <0.01). The ratios of CD3, CD4, CD8 and CD4 / CD8 in peripheral blood lymphocytes were also significantly different (P <0.01). Correlation analysis showed that LADA activity and CD4 / CD8 ratio also showed a highly negative correlation (P <0.01). It is suggested that there is a close relationship between the increase of LADA activity and the imbalance of T lymphocyte subsets in cirrhotic patients.