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目的:分析多烯磷脂酰胆碱对妊娠期肝内胆汁淤积症患者血清白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)水平的影响及临床疗效。方法:选择我院2014年6月~2016年6月收治的102例妊娠期肝内胆汁淤积症患者,按抽签法分为对照组与观察组,各51例。对照组行常规治疗,观察组在对照组治疗基本上加以多烯磷脂酰胆碱治疗,比较两组治疗前后IL-17、TNF-α、TGF-β、血管内皮生长因子(VEGF)、总胆汁酸(TBA),直接胆红素(DBi L)、总胆红素(TBi L)、谷草转移氨酶(AST)、谷丙转氨酶(ALT)、瘙痒评分的变化、有效率及妊娠结局。结果:治疗后,观察组血清IL-17、TNF-α、TGF-β、VEGF、TBA、DBi L、TBi L、AST、ALT水平及瘙痒评分均显著低于对照组,有效率明显高于对照组,不良妊娠结局率显著低于对照组,差异均有统计学意义(P<0.05)。结论:多烯磷脂酰胆碱可有效提高妊娠期肝内胆汁淤积症的临床疗效,降低血清IL-17、TNF-α、TGF-β水平,改善妊娠结局。
Objective: To investigate the effect of polyene phosphatidylcholine on the expression of serum interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β) in patients with intrahepatic cholestasis of pregnancy ) Level and clinical effect. Methods: A total of 102 patients with intrahepatic cholestasis of pregnancy admitted from June 2014 to June 2016 in our hospital were divided into the control group and the observation group according to the way of lottery, each with 51 cases. The control group received conventional therapy. The observation group was treated with polyene phosphatidylcholine in the control group. The levels of IL-17, TNF-α, TGF-β, VEGF, total bile TBA, DBiL, TBiL, AST, ALT, pruritus score, effective rate and pregnancy outcome. Results: After treatment, the levels of IL-17, TNF-α, TGF-β, VEGF, TBA, DBi L, TBi L, AST, ALT and pruritus in the observation group were significantly lower than those in the control group Group, adverse pregnancy outcomes were significantly lower than the control group, the difference was statistically significant (P <0.05). CONCLUSION: Polyene phosphatidylcholine can effectively improve the clinical efficacy of intrahepatic cholestasis of pregnancy, reduce the levels of serum IL-17, TNF-α and TGF-β, and improve the pregnancy outcome.